Comparative Physiology Natural Animal Models And Clinical Medicine

Author: Michael A Singer
Publisher: World Scientific
ISBN: 1908979305
Size: 73.57 MB
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This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the “research” that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection. Contents:IntroductionDiabetes MellitusChronic Renal FailureAtherosclerotic Vascular DiseaseDisuse Osteoporosis and Disuse Muscle AtrophyAmmonia ToxicityHypoxia/IschemiaEpilogue Readership: Advanced undergraduate and graduate students in biology, medical scientists, comparative physiologists and biologists. Keywords:Comparative;Physiology;Models;Clinical Medicine;NaturalKey Features:Discusses in detail for each of six clinical disorders the current understanding of the pathogenesis of the disorder and how the natural animal model has solved that particular problemSuggests potential research questions based upon what is known and not known about the natural animal modelClearly illustrates that natural animal models not only provide a different perspective from traditional animal models, but also prove that biological solutions currently exist for different human diseasesHighlights the power of a comparative physiological approach to the development of treatments for human diseasesReviews:“This is an interesting and important book … A few of these questions about natural models for disease have been raised before by comparative physiologists, but they have largely been ignored by those involved in medical research. Dr Singer hopes that a presentation by a clinician will correct this situation. I sincerely hope that he is correct for I agree with his basic thesis.”Professor Emeritus William H Dantzler University of Arizona “Michael Singer has produced a marvellous volume of thought provoking observations … This volume presents a tour de force of integrative and comparative physiology to consider the possible answers to such questions … For many reasons, I cannot recommend this splendid book highly enough.”Troels Ring Aalborg Hospital, Denmark “The style is easily readable, with a logical progression from a clinical setting in the Introduction, through a number of common disease entities … There is a satisfying combination of science and art, and a call for further research in each area … The book is suitable for medical professionals of all levels of training and interests, from the Basic Scientist in the laboratory to the Clinician at the bedside.”Professor A R Morton Queen's University, Ontario

Comparative Animal Physiology

Author: Philip Carew Withers
Publisher: Brooks/Cole Publishing Company
Size: 11.20 MB
Format: PDF, Mobi
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This truly comparative text takes a fundamental, biophysical approach toward animal physiology. Students majoring in zoology, biology, or premedicine will study animals ranging from simple invertebrates and protozoans to complex multicellular invertebrates and vertebrates. Emphasis on evolution shows the progressive changes, modifications, and developments of physiological systems from simple to complex animals. Comparisons show the similarities and differences in how animals function, but stress fundamentally similar adaptations in very different animals.

Comparative Biology Of The Normal Lung

Author: Richard A. Parent
Publisher: Academic Press
ISBN: 0124047262
Size: 38.37 MB
Format: PDF, Docs
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Comparative Biology of the Normal Lung, 2nd Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system

Comparative Physiology Of The Vertebrate Digestive System

Author: C. Edward Stevens
Publisher: Cambridge University Press
ISBN: 9780521617147
Size: 65.77 MB
Format: PDF, ePub
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This book is useful for anyone interested in the basic structural and functional characteristics of the digestive system and how these vary among vertebrate groups and species. It discusses all of the major aspects of nutrition, anatomy and physiology in all of the major groups of vertebrates. It contains numerous figures and tables to aid in their comparison, including many illustrations of gastrointestinal tracts of vertebrates prepared so as to allow for direct comparison. The terminology of scientific specialties and sub-specialties is defined and animals are referred to by both their common and scientific names. Relationships between digestive strategies and the diet and environment are discussed throughout the text, and brought together in a chapter on the evolution of the digestive system. The final chapter offers a brief summary of the major concepts and suggests future directions for research.

Oxidative Stress In Aquatic Ecosystems

Author: Doris Abele
Publisher: John Wiley & Sons
ISBN: 1444345966
Size: 49.86 MB
Format: PDF, ePub
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Reactive oxygen species (ROS) are increasingly appreciated as down-stream effectors of cellular damage and dysfunction under natural and anthropogenic stress scenarios in aquatic systems. This comprehensive volume describes oxidative stress phenomena in different climatic zones and groups of organisms, taking into account specific habitat conditions and how they affect susceptibility to ROS damage. A comprehensive and detailed methods section is included which supplies complete protocols for analyzing ROS production, oxidative damage, and antioxidant systems. Methods are also evaluated with respect to applicability and constraints for different types of research. The authors are all internationally recognized experts in particular fields of oxidative stress research. This comprehensive reference volume is essential for students, researchers, and technicians in the field of ROS research, and also contains information useful for veterinarians, environmental health professionals, and decision makers.

Comparative Physiology Of Thermoregulation

Author: G. Causey Whittow
Publisher: Academic Press
ISBN: 1483257436
Size: 51.32 MB
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Comparative Physiology of Thermoregulation, Volume III: Special Aspects of Thermoregulation attempts to do three things: It completes the taxonomic organization of the first two volumes, with a chapter on the ""primitive"" mammals. It deals with special aspects of thermoregulation. Aquatic mammals must be considered in this category because they are the only ""warm-blooded"" animals that live in a medium which has an enormous cooling power compared with that of air. Torpidity is a dramatic thermoregulatory phenomenon displayed by only certain groups of mammals, while the newborn mammal faces special problems in thermoregulation that distinguish it from the adult. Finally, the last chapter complements the arrangement of the first two volumes by its treatment of the evolution of thermoregulation from the standpoint of physiological systems rather than classes of animals. It was initially hoped that this three-volume treatise would provide a useful reference work for the comparative physiologist. The reception accorded to the first two volumes suggests that this hope has been largely realized. However, it appears that the books have their greatest appeal to those engaged in the study of physiological ecology, and this lends to the work a currency which was not entirely anticipated at the time of its conception.

Issues In Physiology Cell Biology And Molecular Medicine 2011 Edition

Publisher: ScholarlyEditions
ISBN: 1464965463
Size: 18.91 MB
Format: PDF, Kindle
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Issues in Physiology, Cell Biology, and Molecular Medicine: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Physiology, Cell Biology, and Molecular Medicine. The editors have built Issues in Physiology, Cell Biology, and Molecular Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Physiology, Cell Biology, and Molecular Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Physiology, Cell Biology, and Molecular Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Fish Physiology Recent Advances

Author: Stefan Nilsson
Publisher: Springer Science & Business Media
ISBN: 9401165580
Size: 51.77 MB
Format: PDF
View: 1975
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Fishes are very successful vertebrates and have adapted to a wide range of environmental conditions, from the deep ocean to the smallest brook or pond. The physiological background to these environmental adaptations is, obviously, far from clear, and provides fish physiologists with many challenges. The number of extant fish species has been estimated to be in excess of 20000, and only relatively few of these have been subject to physiological studies. Yet among these animals can be found many physiological systems different from those of the land-dwelling vertebrates, and also systems similar to those of the 'higher' vertebrates but at a different level of phylogenetic development. Apart from the rapidly increasing interest in basic fish physi ology, the last few years have seen a dramatic increase in applied research, aimed primarily in two directions: fish culture and envi ronmental toxicology. Physiological research is of vital importance in both these fields, and basic fish physiology is a necessary base for the applied research. This book is intended for a wide readership among senior undergraduate, postgraduate and research students, as well as uni versity teachers and researchers in zoology, physiology, aqua culture and biology generally. The book focuses on five major areas of basic and applied research: haemopoiesis, acid-base regu lation, circulation, gastro-intestinal functions and physiological toxicology. The chapters will serve as introductions to these fields, as well as up-to-date reviews of the most recent advances in the research areas.