The Family Gene

Author: Joselin Linder
Publisher: HarperCollins
ISBN: 0062378929
Size: 24.20 MB
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A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.

The Family Gene

Author: Joselin Linder
Publisher: Ecco
ISBN: 9780062378897
Size: 75.58 MB
Format: PDF, ePub
View: 266
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A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.

Mercies In Disguise

Author: Gina Kolata
Publisher: St. Martin's Press
ISBN: 1250123992
Size: 69.36 MB
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"[Kolata] is a gifted storyteller. Her account of the Baxleys... is both engrossing and distressing... Kolata's book raises crucial questions about knowledge that can be both vital and fatal, both pallative and dangerous." —Andrew Solomon, The New York Review of Books New York Times science reporter Gina Kolata follows a family through genetic illness and one courageous daughter who decides her fate shall no longer be decided by a genetic flaw. The phone rings. The doctor from California is on the line. “Are you ready Amanda?” The two people Amanda Baxley loves the most had begged her not to be tested—at least, not now. But she had to find out. If your family carried a mutated gene that foretold a brutal illness and you were offered the chance to find out if you’d inherited it, would you do it? Would you walk toward the problem, bravely accepting whatever answer came your way? Or would you avoid the potential bad news as long as possible? In Mercies in Disguise, acclaimed New York Times science reporter and bestselling author Gina Kolata tells the story of the Baxleys, an almost archetypal family in a small town in South Carolina. A proud and determined clan, many of them doctors, they are struck one by one with an inscrutable illness. They finally discover the cause of the disease after a remarkable sequence of events that many saw as providential. Meanwhile, science, progressing for a half a century along a parallel track, had handed the Baxleys a resolution—not a cure, but a blood test that would reveal who had the gene for the disease and who did not. And science would offer another dilemma—fertility specialists had created a way to spare the children through an expensive process. A work of narrative nonfiction, Mercies in Disguise is the story of a family that took matters into its own hands when the medical world abandoned them. It’s a story of a family that had to deal with unspeakable tragedy and yet did not allow it to tear them apart. And it is the story of a young woman—Amanda Baxley—who faced the future head on, determined to find a way to disrupt her family’s destiny.

The Inheritance

Author: Niki Kapsambelis
Publisher: Simon and Schuster
ISBN: 1451697333
Size: 62.21 MB
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This gripping story of the doctors at the forefront of Alzheimer’s research and the courageous North Dakota family whose rare genetic code is helping to understand our most feared diseases is “excellent, accessible...A science text that reads like a mystery and treats its subjects with humanity and sympathy” (Library Journal, starred review). Every sixty-nine seconds, someone is diagnosed with Alzheimer’s disease. Of the top ten killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer’s, an inherited genetic mutation that causes the disease in one hundred percent of cases, and has a fifty percent chance of being passed onto the next generation. Of the six DeMoe children whose father had it, five have inherited the gene; the sixth, daughter Karla, has inherited responsibility for all of them. But rather than give up in the face of such news, the DeMoes have agreed to spend their precious, abbreviated years as part of a worldwide study that could utterly change the landscape of Alzheimer’s research and offers the brightest hope for future treatments—and possibly a cure. Drawing from several years of in-depth research with this charming and upbeat family, journalist Niki Kapsambelis tells the story of Alzheimer’s through the humanizing lens of these ordinary people made extraordinary by both their terrible circumstances and their bravery. “A compelling narrative…and an educational and emotional chronicle” (Kirkus Reviews, starred review), their tale is intertwined with the dramatic narrative history of the disease, the cutting-edge research that brings us ever closer to a possible cure, and the accounts of the extraordinary doctors spearheading these groundbreaking studies. From the oil fields of North Dakota to the jungles of Colombia, this inspiring race against time redefines courage in the face of this most pervasive and mysterious disease.

Gender And Development

Author: Janet Momsen
Publisher: Routledge
ISBN: 113527519X
Size: 15.78 MB
Format: PDF, ePub
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Global financial problems, rising food prices, climate change, international migration – increasingly by women – conflict situations in many poor countries, the spread of tropical diseases such as malaria and dengue fever and the increased incidence of HIV/AIDS and TB, and changing patterns of trade have all added new dimensions to gender issues in developing countries. These problems are frequently being brought to public attention in the media and through long-haul tourism. Consequently students’ interest in gender and development has grown considerably in the last few years. This updated second edition provides a concise, accessible introduction to Gender and Development issues in the developing world and in the transition countries of Eastern and Central Europe. The nine chapters include discussions on changes in theoretical approaches, gender complexities and the Millennium Development Goals; social and biological reproduction including differing attitudes to family planning by states and variation in education and access to housing; differences in health and violence at major life stages for women and men and natural disasters and gender roles in rural and urban areas. The penultimate chapter considers the impact of broad economic changes such as the globalization of trade and communications on gender differences in economic activity and the final chapter addresses international progress towards gender equality as measured by the global gender gap. The text is particularly strong on environmental aspects and the new edition builds on this to consider the effects of climate change and declining natural resources illustrated by a case study of changing gender roles in fishing in India. There is also enhanced coverage of topics such as global trade, sport as a development tool, masculinities, and sustainable agriculture. Maps, statistics, references and boxed case studies have been updated throughout and their coverage widened. Gender and Development is the only broad based introduction to the topic written specifically for a student audience. It features student friendly items such as chapter learning objectives, discussion questions, annotated guides to further reading and websites. The text is enlivened throughout with examples and case studies drawn from the author’s worldwide field research and consultancies with international development agencies over four decades and her experience of teaching the topic to undergraduates and postgraduates in many countries. It will be an essential text for a variety of courses on development, women’s studies, sociology, anthropology and geography.

What This Cruel War Was Over

Author: Chandra Manning
Publisher: Vintage
ISBN: 0307267431
Size: 54.22 MB
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In this unprecedented account, Chandra Manning uses letters, diaries, and regimental newspapers to take the reader inside the minds of Civil War soldiers-black and white, Northern and Southern-as they fought and marched across a divided country. With stunning poise and narrative verve, Manning explores how the Union and Confederate soldiers came to identify slavery as the central issue of the war and what that meant for a tumultuous nation. This is a brilliant and eye-opening debut and an invaluable addition to our understanding of the Civil War as it has never been rendered before. From the Trade Paperback edition.

Strange Haven

Author: Sigmund Tobias
Publisher: University of Illinois Press
ISBN: 9780252024535
Size: 53.32 MB
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The author, part of the Jewish refugee community in Shanghai, tells of his experiences growing up in the ghetto under Japanese occupation.

The Stoned Family Robinson

Author: J.D. Wyss
Publisher: Simon and Schuster
ISBN: 1440525706
Size: 22.62 MB
Format: PDF, Mobi
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"For many days we had been tempest-tossed - and our stash was soaked. Six times had the darkness closed over a gnarly scene, and returning light as often brought a renewed jones while the storm raged on and after seven days all hope was lost of finding that magical island to grow our free-range weed unnoticed by narcs." Forget the classic you knew as a child; you've never seen the Robinsons have so much fun being shipwrecked - until now. In this "highlarious" update of the beloved family adventure, you can smoke up with the whole Robinson family while they are shipwrecked on an uncharted tropical island. From constructing a home made entirely of weed and sampling the millions of strains of pot they find on the island to trying to make a bong out of a coconut, this book will leave you jonesing for more!

Hope And Other Dangerous Pursuits

Author: Laila Lalami
Publisher: Houghton Mifflin Harcourt
ISBN: 9780156030878
Size: 52.94 MB
Format: PDF, ePub, Docs
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Set in modern-day Morocco, the story of four vastly different Moroccans who illegally cross the Strait of Gibraltar in an inflatable boat headed for Spain chronicles the circumstances that drive them to risk their lives and the rewards that may or may not prove to be worth the danger. Reprint.

Moral Courage

Author: Rushworth M. Kidder
Publisher: Harper Collins
ISBN: 0061749788
Size: 25.78 MB
Format: PDF, ePub
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Why did a group of teenagers watch a friend die instead of putting their own reputations at risk? Why did a top White House official decide to come clean and accept a prison sentence during Watergate? Why did a finance executive turn down millions out of respect for her employer? Why are some willing to risk their futures to uphold principles? What gives us the strength to stand up for what we believe? As these questions suggest, the topic of moral courage is front and center in today's culture. Enron, Arthur Andersen, the U.S. Olympic Committee, abusive priests, cheating students, domestic violence -- all these remind us that taking ethical stands should be a higher priority in our culture. Why, when people discern wrongdoing, are they sometimes unready, unable, or unwilling to act? In a book rich with examples, Rushworth Kidder reveals that moral courage is the bridge between talking ethics and doing ethics. Defining it as a readiness to endure danger for the sake of principle, he explains that the courage to act is found at the intersection of three elements: action based on core values, awareness of the risks, and a willingness to endure necessary hardship. By exploring how moral courage spurs us to strive for core values, he demonstrates the benefits of ethical action to the individual and to society -- and the severe consequences that can result from remaining morally dormant. Moral Courage puts indispensable concepts and tools into our hands, equipping us to respond to the increasingly complicated moral challenges we face at work, at home, and in our communities. It enables us to make clear, confident decisions by exploring some litmus-test questions: Is the benefit worth the risk? Am I motivated by my desire to uphold my beliefs or just to impose them on others? Will my actions create collateral damage among those with no stake in the outcome? While physical courage may no longer be a necessary survival skill or an essential rite of passage out of childhood, few would dispute the growing need for moral courage as the true gauge of maturity. Treating this subject not as an esoteric branch of philosophy but as a practical necessity for modern life, Kidder deftly leads us to a clear understanding of what moral courage is, what it does, and how to get it.